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Welcome to the Sternberg Lab! 

Our laboratory is interested in the systems biology of nematodes.  We seek to understand how the properties of an organism are encoded in its genome.

Lab News

September 2017.  We were awared a  two-year grant from the NIH-NIMH to generate cGAL drivers for every neuron class and test them by perturbing neurons during male mating behavior.

January 2018.  We were featured in Caltech's news.  The article can be found here.

September 10, 2018.  Pei-Yin Shih defended her thesis entitled "The Ethology of Stress in Nematodes".

Strain/Reagent Requests

To request and published strain or reagent, please email Barbara Perry.  For unpublished strains or reagents, please email Paul Sternberg.

New Publications

1. Ho MCW, Quintero-Cadena P, Sternberg PW. Genome-wide discovery of active regulatory elements and transcription factor footprints in Caenorhabditis elegans using DNase-seq. Genome Res. 2017 Dec;27(12):2108-2119. doi: 10.1101/gr.223735.117. Epub 2017 Oct 26. PubMed PMID: 29074739; PubMed Central PMCID: PMC5741056.

2. Lee RYN, Howe KL, Harris TW, Arnaboldi V, Cain S, Chan J, Chen WJ, Davis P, Gao S, Grove C, Kishore R, Muller HM, Nakamura C, Nuin P, Paulini M, Raciti D, Rodgers F, Russell M, Schindelman G, Tuli MA, Van Auken K, Wang Q, Williams G, Wright A, Yook K, Berriman M, Kersey P, Schedl T, Stein L, Sternberg PW. WormBase 2017: molting into a new stage. Nucleic Acids Res. 2018 Jan 4;46(D1):D869-D874. doi: 10.1093/nar/gkx998. PubMed PMID: 29069413; PubMed Central PMCID: PMC5753391.

3. Schwartz, H.T., & Sternberg, P.W. A Toolkit of Engineered Recombinational Balancers in C. elegans. Trends Genet. 2018 doi: 10.1016/j.tig.2018.01.009.

4. Angeles-Albores D, Puckett Robinson C, Williams BA, Wold BJ, Sternberg PW. Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements. Proc Natl Acad Sci U S A. 2018 Mar 12. pii: 201712387. doi: 10.1073/pnas.1712387115. [Epub ahead of print] PubMed PMID: 29531064.

5. Müller HM, Van Auken KM, Li Y, Sternberg PW. Textpresso Central: a customizable platform for searching, text mining, viewing, and curating biomedical literature. BMC Bioinformatics. 2018 Mar 9;19(1):94. doi: 10.1186/s12859-018-2103-8. PubMed PMID: 29523070.

6. Artyukhin AB, Zhang YK, Akagi AE, Panda O, Sternberg PW, Schroeder FC. Metabolomic "Dark Matter" Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans. J Am Chem Soc. 2018 Feb 28;140(8):2841-2852. doi: 10.1021/jacs.7b11811. Epub 2018 Feb 16. PubMed PMID: 29401383.

7. Wang H, Liu J, Yuet KP, Hill AJ, Sternberg PW. (2018) Split cGAL, an intersectional strategy using a split intein for refined spatiotemporal transgene control in C. elegans. PNAS. https://doi.org/10.1073/pnas.1720063115. [Epub ahead of print]

8.  Angeles-Albores D, Sternberg PW. Using Transcriptones as Mutant Phenotypes Reveals Functional Regions of a Mediator Subunit in Caenorhabditis elegans. Genetics. 2018 July 23. https://doi.org/10.1534/genetics.118.301133.  

 

9. Wang H, Park H, Liu J, Sternberg PW.  An Efficient Genome Editing Strategy to Generate Putative Null Mutants in Caenorhabditis elegans Using CRISPR/Cas9.  G3: Genes, Genome, Genetics.  Early online September 17, 2018; https://doi.org/10.1534/g3.118.200662.

New Micropublications

Hadju-Cronin YM, Liu KS, Barber L, Chamberlin HM, Boorstein W, Sternberg PW. (2017) Copulation defective mutants of C. elegans Micropublication:biology.  Dataset.  https://doi.org/10.17912/W2XH3S.

Whittaker A, Schindelman G, Gharib S, Sternberg PW.  (2017)  A new mutation with a polycyctin phenotypic spectrum in Caenorhabditits elegans.  Micropublication:biology.  Dataset.  https://doi.org/10.17912/W2N37P.

Angeles-Albores D, Lee RYN, Chan J, Sternberg PW. (2018) Two new functions in the WormBase Enrichment Suite. Micropublication: biology. Dataset. https://doi.org/10.5072/FK2M909045

Cao M, Chai C, Liu J, Sternberg PW. (2018) Application of the red-shifted channelrhodospin Chrimson for the Caenorhabdidits elegans cGAL bipartite system.  Micropublication:biology.  Dataset. https://doi.org/10.17912/2JGW-FJ52