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Welcome to the Sternberg Lab! 

Our laboratory is interested in the systems biology of nematodes.  We seek to understand how the properties of an organism are encoded in its genome.

Lab News

September 10, 2018.  Pei-Yin Shih defended her thesis entitled "The ethology of stress in nematodes".

September 18, 2018.  David Angeles defended his thesis entitled "A theory of genetic analysis using transcriptomic phenotypes".

September 25, 2018.  James Lee defended his thesis entitled "The genomics of stree-induced life cycle decisions in nematodes"

Strain/Reagent Requests

To request a published strain or reagent, please email Barbara Perry.  For unpublished strains or reagents, please email Paul Sternberg.

New Publications

1. Lee RYN, Howe KL, Harris TW, Arnaboldi V, Cain S, Chan J, Chen WJ, Davis P, Gao S, Grove C, Kishore R, Muller HM, Nakamura C, Nuin P, Paulini M, Raciti D, Rodgers F, Russell M, Schindelman G, Tuli MA, Van Auken K, Wang Q, Williams G, Wright A, Yook K, Berriman M, Kersey P, Schedl T, Stein L, Sternberg PW. WormBase 2017: molting into a new stage. Nucleic Acids Res. 2018 Jan 4;46(D1):D869-D874. doi: 10.1093/nar/gkx998. PubMed PMID: 29069413; PubMed Central PMCID: PMC5753391.

2. Schwartz, H.T., & Sternberg, P.W. A Toolkit of Engineered Recombinational Balancers in C. elegans. Trends Genet. 2018 doi: 10.1016/j.tig.2018.01.009.

3. Angeles-Albores D, Puckett Robinson C, Williams BA, Wold BJ, Sternberg PW. Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements. Proc Natl Acad Sci U S A. 2018 Mar 12. pii: 201712387. doi: 10.1073/pnas.1712387115. [Epub ahead of print] PubMed PMID: 29531064.

4. Müller HM, Van Auken KM, Li Y, Sternberg PW. Textpresso Central: a customizable platform for searching, text mining, viewing, and curating biomedical literature. BMC Bioinformatics. 2018 Mar 9;19(1):94. doi: 10.1186/s12859-018-2103-8. PubMed PMID: 29523070.

5. Artyukhin AB, Zhang YK, Akagi AE, Panda O, Sternberg PW, Schroeder FC. Metabolomic "Dark Matter" Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans. J Am Chem Soc. 2018 Feb 28;140(8):2841-2852. doi: 10.1021/jacs.7b11811. Epub 2018 Feb 16. PubMed PMID: 29401383.

6. Wang H, Liu J, Yuet KP, Hill AJ, Sternberg PW. (2018) Split cGAL, an intersectional strategy using a split intein for refined spatiotemporal transgene control in C. elegans. PNAS. https://doi.org/10.1073/pnas.1720063115. [Epub ahead of print]

7.  Angeles-Albores D, Sternberg PW. Using Transcriptones as Mutant Phenotypes Reveals Functional Regions of a Mediator Subunit in Caenorhabditis elegans. Genetics. 2018 July 23. https://doi.org/10.1534/genetics.118.301133

8. Wang H, Park H, Liu J, Sternberg PW.  An Efficient Genome Editing Strategy to Generate Putative Null Mutants in Caenorhabditis elegans Using CRISPR/Cas9.  G3: Genes, Genome, Genetics.  November 1, 2018 8(11):3607-3616; https://doi.org/10.1534/g3.118.200662.

9. Sternberg PW. Opening up a large can of worms. Parasite Genomics. 04 December 2018. http://doi.org/10.1038/s41588-018-0317-3.

New Micropublications

Hadju-Cronin YM, Liu KS, Barber L, Chamberlin HM, Boorstein W, Sternberg PW. (2017) Copulation defective mutants of C. elegans Micropublication:biology.  Dataset.  https://doi.org/10.17912/W2XH3S.

Whittaker A, Schindelman G, Gharib S, Sternberg PW.  (2017)  A new mutation with a polycyctin phenotypic spectrum in Caenorhabditits elegans.  Micropublication:biology.  Dataset.  https://doi.org/10.17912/W2N37P.

Angeles-Albores D, Lee RYN, Chan J, Sternberg PW. (2018) Two new functions in the WormBase Enrichment Suite. Micropublication: biology. Dataset. https://doi.org/10.5072/FK2M909045

Cao M, Chai C, Liu J, Sternberg PW. (2018) Application of the red-shifted channelrhodospin Chrimson for the Caenorhabdidits elegans cGAL bipartite system.  Micropublication:biology.  Dataset. https://doi.org/10.17912/2JGW-FJ52

Cho J, Grove C, Van Auken K, Chan J, Gao S, Sternberg PW. (2018) Update on protein-protein interaction data in WormBase. Micropublication:biology. Dataset. http://doi.org/10.17912/micropub.biology.000074.