I discovered roles for the mechanoreceptor piezo in C. elegans male mating behavior.
I'm broadly interested in the neural and genetic basis of C. elegans diapause entry. I currently study the roles of a) the first-layer amphid interneurons and b) the transcription factor FKH-7 in mediating the dauer entry decision.
I am interested in using proteomic methods to study the composition of C. elegans Excreted/Secreted products and the roles they play in regulating the molting cycle and growth rate, defense against bacterial infection, pathogen susceptibility.
I study the roles of o-acyltransferases and esterases in the formation of ascarosides, pheromone-like small-molecules used for communication and behavior mediation, in the nematode C. elegans.
I am interested in spectroscopy of biological systems.
To help me analyze the compact pharyengal nervous system of C. elegans which control cardiac muscle like rhythmic contractions, I am applying the cGAL system that I helped develop.
I am interested in understanding how eukaryotic cells can quickly assemble the molecular machinery required to make many copies of RNA from DNA on demand.
I am interested in the functional consequences of ASD-associated missense variants in neurological development and behaviors.
I am interested in studying microbial symbiosis in between the entomopathogenic (insect-parasitic) nematode Steinernema carpocapsae and its beneficial bacterium Xenorhabdus nematophila as a naturally occurring mutualistic symbiosis system.
I am interested in neural mechanisms of mate recognition in C. elegans, especially how males recognize reproductive hermaphrodites for mating by contact-dependent surface cues.
I study how animals and their behaviors change in response to stress, using genetic analysis of the C. elegans dauer as a way into the problem.
I am developing whole animal-transcriptomes as phenotypes for use in genetic analysis.
I’m interested in how animal behaviors are affected by the environment and life experience.
I study the molecular and circuit mechanisms underlying sleep regulation and function. I'm also interested in developing genetic tools, including cGAL and split cGAL for precise transgene control and CRISPR/Cas9 for genome editing.
One of the projects I'm working on involves constructing collections of cGAL/split cGAL driver and effector lines for neuron specific expression and gene control.
My work explores the use of RNA-seq to study genetic interactions within and between pathways.
One of the projects I'm working on focuses on generating new null mutants in C. elegans. I use CRISPR/Cas9 based simple and efficient knock-in methods such as STOP-IN cassette insertion.