I'm broadly interested in the neural and genetic basis of C. elegans diapause entry. I currently study the roles of a) the first-layer amphid interneurons and b) the transcription factor FKH-7 in mediating the dauer entry decision.
I am interested in using proteomic methods to study the composition of C. elegans Excreted/Secreted products and the roles they play in regulating the molting cycle and growth rate, defense against bacterial infection, pathogen susceptibility.
I study the roles of o-acyltransferases and esterases in the formation of ascarosides, pheromone-like small-molecules used for communication and behavior mediation, in the nematode C. elegans.
I am interested in understanding how eukaryotic cells can quickly assemble the molecular machinery required to make many copies of RNA from DNA on demand.
I am interested in studying microbial symbiosis in between the entomopathogenic (insect-parasitic) nematode Steinernema carpocapsae and its beneficial bacterium Xenorhabdus nematophila as a naturally occurring mutualistic symbiosis system.
I am interested in neural mechanisms of mate recognition in C. elegans, especially how males recognize reproductive hermaphrodites for mating by contact-dependent surface cues.
I am developing whole animal-transcriptomes as phenotypes for use in genetic analysis.
I study the molecular and circuit mechanisms underlying sleep regulation and function. I'm also interested in developing genetic tools, including cGAL and split cGAL for precise transgene control and CRISPR/Cas9 for genome editing.